anti- Collagen Type IV antibody

Dive into the world of basement membranes and tissue scaffolding with our Anti-Collagen Type IV Antibody, available in a convenient 100µg size. Collagen Type IV is a foundational component of basement membranes, critical for tissue structure and barrier function. This high-quality antibody is your essential tool for investigating tissue integrity and cellular interactions.

Our antibody is meticulously designed and rigorously validated to ensure specificity and sensitivity, ensuring accurate and reproducible results in your experiments. Whether you're exploring tissue development, angiogenesis, or the role of basement membranes in disease, this antibody will be your reliable research companion.

The 100µg size provides a generous supply of antibody to support your experiments without the hassle of frequent reordering. Choose our Anti-Collagen Type IV Antibody to advance your scientific endeavors and contribute to a deeper understanding of basement membrane biology.

Product Name

Collagen Type IV antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

IMMUNOGEN INFORMATION

Immunogen

collagen, type IV, alpha 2

Synonyms

COL4A2, Collagen alpha 2(IV) chain, Collagen Type IV, collagen, type IV, alpha 2, DKFZp686I14213, FLJ22259

Observed MW

200 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P08572

IMAGES

Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab01844(Collagen Type IV antibody) at dilution of 1:50

NIH/3T3 were subjected to SDS PAGE followed by western blot with FNab01844(Collagen Type IV Antibody) at dilution of 1:1000