anti- COMMD1 antibody

Delve into the intricacies of cellular homeostasis and protein regulation with our Anti-COMMD1 Antibody, meticulously developed and available in a convenient 100µg size. COMMD1, also known as MURR1, is a multifunctional protein involved in diverse cellular processes, including the regulation of copper homeostasis, NF-κB signaling, and vesicular trafficking.

Our antibody is designed with precision and rigorously validated to ensure specificity and sensitivity, enabling accurate and reproducible results in your experiments. Whether you're investigating immune responses, copper metabolism disorders, or the role of COMMD1 in cancer biology, this antibody is your trusted research partner.

The 100µg size provides a substantial quantity of antibody for your experiments, minimizing the need for frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COMMD1 Antibody to advance your scientific exploration of cellular regulation and contribute to a deeper understanding of COMMD1's diverse functions in health and disease.

Product Name

COMMD1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2(PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity(PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2(PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel(ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes(PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination(PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization(PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes(PubMed:25355947). Can bind one copper ion per monomer(PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2)(PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1(PubMed:20458141).

IMMUNOGEN INFORMATION

Immunogen

copper metabolism(Murr1) domain containing 1

Synonyms

C2orf5, MURR1

Observed MW

21 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q8N668

IMAGES

Immunohistochemistry of paraffin-embedded human liver cancer using FNab01850(COMMD1 antibody) at dilution of 1:50

IP Result of anti-COMMD1 (IP:FNab01850, 3ug; Detection:FNab01850 1:500) with mouse brain tissue lysate 5200ug.

human liver tissue were subjected to SDS PAGE followed by western blot with FNab01850(COMMD1 antibody) at dilution of 1:1000