anti- COMT antibody

Embark on a journey into the world of neurotransmitter metabolism with our Anti-COMT Antibody, meticulously crafted and conveniently available in a 100µg size. Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of catecholamine neurotransmitters, such as dopamine, in the central nervous system. This high-quality antibody is your indispensable tool for investigating the intricate regulation of neurotransmitter levels and its implications in neurological and psychiatric disorders.

Our antibody is designed to provide specificity and sensitivity, ensuring accurate and reproducible results in your research. Whether you're exploring the role of COMT in dopamine-related disorders like Parkinson's disease or investigating the impact of COMT polymorphisms on cognitive function, this antibody is your trusted research partner.

The 100µg size offers a substantial supply of antibody to support your experiments, reducing the inconvenience of frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COMT Antibody to advance your scientific exploration of neurotransmitter metabolism and contribute to a deeper understanding of its significance in brain function and health.

Uncovering the mechanisms underlying neurotransmitter regulation by COMT is essential for deciphering the complexities of brain function and its relevance to neurological and psychiatric conditions. Our antibody empowers you to delve into this intriguing area of research, potentially paving the way for novel therapeutic interventions and improved patient care.

Product Name

COMT antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

IMMUNOGEN INFORMATION

Immunogen

catechol-O-methyltransferase

Observed MW

28 kDa, 32 kDa

APPLICATION

Tested Application

ELISA, IHC, IF, WB

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P21964

IMAGES

Immunohistochemistry of paraffin-embedded rat kidney using FNab01856(COMT antibody) at dilution of 1:100

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab01856( COMT Antibody) at dilution of 1:1000