anti- COPS3 antibody

Embark on a journey into the world of protein regulation and cellular responses with our Anti-COPS3 Antibody, meticulously developed and conveniently available in a 100µg size. COPS3, a crucial subunit of the COP9 signalosome (CSN) complex, plays a central role in protein ubiquitination, degradation, and the modulation of cellular signaling pathways. This high-quality antibody serves as your indispensable tool for investigating the dynamic processes of protein stability and cellular responses to environmental cues.

Our antibody is designed with precision and rigorously validated to ensure specificity and sensitivity, guaranteeing accurate and reproducible results in your research. Whether you're exploring proteasomal degradation pathways, cellular responses to stress, or the role of COPS3 in cancer biology, this antibody is your trusted research partner.

The 100µg size provides a substantial supply of antibody for your experiments, reducing the hassle of frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COPS3 Antibody to advance your scientific exploration of protein regulation and contribute to a deeper understanding of cellular responses to environmental cues.

Understanding the role of COPS3 in protein stability and cellular signaling is crucial for deciphering the complexities of cellular responses to stimuli and their relevance to various diseases. Our antibody empowers you to delve into this intriguing area of research, potentially paving the way for novel therapeutic interventions and improved patient care.

Product Name

COPS3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

IMMUNOGEN INFORMATION

Immunogen

COP9 constitutive photomorphogenic homolog subunit 3(Arabidopsis)

Synonyms

CSN3

Observed MW

48 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UNS2

IMAGES

Immunohistochemistry of paraffin-embedded human kidney using FNab01871(COPS3 antibody) at dilution of 1:100

human brain tissue were subjected to SDS PAGE followed by western blot with FNab01871(COPS3 antibody) at dilution of 1:500