anti- COPS4 antibody

Dive into the fascinating world of intracellular protein regulation with our Anti-COPS4 Antibody, meticulously developed and available in a convenient 100µg size. COPS4, a vital subunit of the COP9 signalosome (CSN) complex, plays a central role in protein stability, ubiquitination, and cellular responses to environmental cues. This high-quality antibody serves as your essential tool for investigating the dynamic processes of protein degradation and signaling.

Our antibody is meticulously crafted and rigorously validated to ensure specificity and sensitivity, guaranteeing accurate and reproducible results in your experiments. Whether you're exploring proteasomal degradation pathways, cellular responses to stress, or the role of COPS4 in cancer biology, this antibody is your dependable research companion.

The 100µg size offers a generous supply of antibody to support your experiments, reducing the inconvenience of frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COPS4 Antibody to advance your scientific exploration of protein regulation and contribute to a deeper understanding of cellular responses to environmental cues.

Unraveling the intricacies of COPS4's role in protein stability and signaling is essential for deciphering the complexities of cellular responses to stimuli and their implications in various diseases. Our antibody empowers you to delve into this intriguing area of research, potentially paving the way for novel therapeutic strategies and improved patient outcomes.

Product Name

COPS4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

IMMUNOGEN INFORMATION

Immunogen

COP9 constitutive photomorphogenic homolog subunit 4(Arabidopsis)

Synonyms

CSN4

Observed MW

40; 46 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9BT78

IMAGES

Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab01872(COPS4 Antibody) at dilution of 1:50

IP Result of anti-COPS4 (IP:FNab01872, 4ug; Detection:FNab01872 1:300) with PC-3 cells lysate 1800ug.

A2780 cells were subjected to SDS PAGE followed by western blot with FNab01872(COPS4 antibody) at dilution of 1:500