anti- COPS7A antibody

Step into the realm of intracellular protein degradation and ubiquitination with our Anti-COPS7A Antibody, meticulously crafted and conveniently available in a 100µg size. COPS7A, also known as CSN7A, is a critical subunit of the COP9 signalosome (CSN) complex, involved in regulating protein stability and modulating cellular responses to environmental cues. This high-quality antibody serves as your indispensable tool for investigating the dynamic processes of protein ubiquitination and deubiquitination.

Our antibody is designed with precision and rigorously validated to ensure specificity and sensitivity, guaranteeing accurate and reproducible results in your research. Whether you're exploring proteasomal degradation pathways, cellular responses to stress, or the role of COPS7A in cancer biology, this antibody is your trusted research partner.

The 100µg size provides a substantial supply of antibody for your experiments, reducing the hassle of frequent reordering and ensuring uninterrupted progress in your research endeavors. Choose our Anti-COPS7A Antibody to advance your scientific exploration of protein regulation and contribute to a deeper understanding of cellular responses to environmental cues.

Understanding the role of COPS7A in protein stability and signaling is crucial for deciphering the complexities of cellular responses to stimuli and their relevance to various diseases. Our antibody empowers you to delve into this intriguing area of research, potentially paving the way for novel therapeutic interventions and improved patient care.

Product Name

COPS7A antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

IMMUNOGEN INFORMATION

Immunogen

COP9 constitutive photomorphogenic homolog subunit 7A(Arabidopsis)

Synonyms

CSN7A, DERP10

Observed MW

30 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UBW8

IMAGES

Immunohistochemistry of paraffin-embedded human kidney using FNab01873(COPS7A antibody) at dilution of 1:50

IP Result of anti-COPS7A (IP:FNab01873, 4ug; Detection:FNab01873 1:300) with mouse heart tissue lysate 4000ug.

human heart tissue were subjected to SDS PAGE followed by western blot with FNab01873(COPS7A antibody) at dilution of 1:300