anti- CRBN antibody

Venture into the world of ubiquitin ligases and protein degradation with our Anti-CRBN Antibody, available in a convenient 100µg size. CRBN (Cereblon) is a critical component of the CRL4(CRBN) E3 ubiquitin ligase complex, involved in the ubiquitination and degradation of specific protein substrates.

This antibody is meticulously designed and rigorously tested for specificity and sensitivity, making it suitable for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Whether you are researching protein homeostasis, ubiquitin-proteasome pathways, or drug discovery, our Anti-CRBN Antibody will provide you with accurate and consistent results.

Trust in the accuracy and reliability of this antibody as you advance your research in molecular biology, protein degradation mechanisms, and related fields. Uncover the molecular mechanisms governing CRBN's roles in protein ubiquitination and degradation with the assistance of this high-quality antibody.

Product Name

CRBN antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

IMMUNOGEN INFORMATION

Immunogen

cereblon

Synonyms

cereblon, CRBN, MRT2A, Protein cereblon

Observed MW

53 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

Q96SW2

IMAGES