anti- CREB3L2 antibody

Dive into the intricate world of transcription factors with our Anti-CREB3L2 Antibody, available in a convenient 100µg size. CREB3L2 (cAMP Response Element-Binding Protein 3-Like 2), also known as BBF2H7, is a transcription factor involved in the unfolded protein response, a critical pathway for maintaining endoplasmic reticulum (ER) homeostasis and protein folding.

This antibody is rigorously validated for specificity and sensitivity, making it suitable for various applications, including chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence. Whether you are studying ER stress, protein folding, or cell survival pathways, our Anti-CREB3L2 Antibody will provide you with precise and reliable results.

Count on this antibody to empower your studies in molecular biology, cell stress responses, and related fields, as you uncover the molecular mechanisms governing ER homeostasis and CREB3L2's roles in maintaining protein quality.

Product Name

CREB3L2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor involved in unfolded protein response(UPR). In the absence of endoplasmic reticulum(ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes(By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death(PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site(PubMed:17178827).

IMMUNOGEN INFORMATION

Immunogen

cAMP responsive element binding protein 3-like 2

Synonyms

BBF2H7

Observed MW

60-70 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q70SY1

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