anti- CREST antibody

Explore the intriguing world of autoimmune diseases and autoantibodies with our Anti-CREST Antibody, available in a convenient 100µg size. CREST (Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, Telangiectasia) is a clinical variant of systemic sclerosis (scleroderma) characterized by specific autoantibodies targeting distinct nuclear antigens.

This antibody is rigorously validated for specificity and sensitivity, making it suitable for various applications, including immunoprecipitation, immunofluorescence, and autoimmune disease research. Whether you are investigating autoimmune disorders, autoantibody profiling, or systemic sclerosis, our Anti-CREST Antibody will provide you with accurate and consistent results.

Trust in the accuracy and reliability of this antibody as you advance your research in immunology, rheumatology, and related fields. Uncover the molecular mechanisms underlying CREST syndrome and autoimmune responses with the assistance of this trusted antibody.

Product Name

CREST antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).

IMMUNOGEN INFORMATION

Immunogen

synovial sarcoma translocation gene on chromosome 18-like 1

Synonyms

CREST, KIAA0693, LP2261, SS18 like protein 1, SS18L1, SYT homolog 1

Observed MW

50 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:1000-1:6000

UNIPROT INFORMATION

UniProt ID

O75177

IMAGES