anti- CSE1L antibody

Embark on a journey into the nucleus of the cell with our Anti-CSE1L Antibody, now available in a convenient 100µg size. CSE1L (Cellular Apoptosis Susceptibility Protein) is a multifunctional protein involved in nucleocytoplasmic transport, protein trafficking, and cellular responses to stress.

This meticulously designed antibody is rigorously validated for specificity and sensitivity, making it suitable for various applications, including immunofluorescence, nuclear transport studies, and investigations into cellular stress responses. Whether you are researching nuclear transport mechanisms, signal transduction, or cellular homeostasis, our Anti-CSE1L Antibody will provide you with accurate and consistent results.

Count on the accuracy and reliability of this antibody as you advance your research in cell biology, molecular genetics, and related fields. Uncover the molecular mechanisms governing CSE1L's roles in nucleocytoplasmic transport and its impact on cellular function with the assistance of this high-quality antibody.

Product Name

CSE1L antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates(cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.

IMMUNOGEN INFORMATION

Immunogen

CSE1 chromosome segregation 1-like(yeast)

Synonyms

CAS, XPO2

Observed MW

100-110 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P55060

IMAGES