anti- CSK antibody

Immerse yourself in the world of CSK (C-Src Tyrosine Kinase) with our Monoclonal Anti-CSK Antibody, now available in a convenient 100µg size. CSK is a critical regulator of intracellular signal transduction, playing a pivotal role in cell growth, differentiation, and immune responses. Its dysregulation is associated with various diseases, making it a promising target for therapeutic intervention.

This meticulously crafted monoclonal antibody is rigorously validated for specificity and sensitivity, making it ideal for applications such as immunohistochemistry, kinase assays, and studies into cancer biology and signal transduction. Whether you are researching CSK's functions in immune cell signaling, its interactions with kinases, or its potential as a drug target, our Monoclonal Anti-CSK Antibody will provide you with precise and reproducible results.

Trust in the accuracy and reliability of this monoclonal antibody as you explore the multifaceted roles of CSK in health and disease. Uncover the molecular mechanisms governing CSK-mediated signaling and its implications for therapeutic targeting and diagnostics with the assistance of this high-quality antibody.

Product Name

CSK antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

IMMUNOGEN INFORMATION

Immunogen

c-src tyrosine kinase

Synonyms

C Src kinase, c src tyrosine kinase, CSK, Protein tyrosine kinase CYL, Tyrosine protein kinase CSK

Observed MW

50 kDa

APPLICATION

Tested Application

ELISA, WB, IF

Recommended Dilution

WB: 1:500-1:2000; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P41240

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