anti- CSNK2A1 antibody

Explore the versatility of our Polyclonal Anti-CSNK2A1 Antibody, now available in a convenient 100µg size, designed to meet your research needs. CSNK2A1 (Casein Kinase 2 Alpha 1), also known as CK2α1, is a pivotal component of the multifunctional serine/threonine protein kinase CK2, which is involved in regulating numerous cellular processes, including cell growth, proliferation, and signaling.

This carefully designed polyclonal antibody undergoes rigorous validation for specificity and sensitivity, making it ideal for various applications, including immunoprecipitation, kinase activity assays, and investigations into CK2-mediated signaling. Whether you are researching CK2α1's roles in disease pathways, its associations with specific substrates, or its potential as a drug target, our Polyclonal Anti-CSNK2A1 Antibody delivers accurate and consistent results.

Count on the versatility, accuracy, and reliability of this polyclonal antibody as you advance your research in kinase biology, cellular signaling, and related fields. Uncover the intricate roles of CSNK2A1 in health and disease, and explore its potential as a therapeutic target with the assistance of this trusted antibody.

Product Name

CSNK2A1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint(SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry(PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue(PubMed:24962073).

IMMUNOGEN INFORMATION

Immunogen

casein kinase 2, alpha 1 polypeptide

Synonyms

Casein kinase II subunit alpha, CK II alpha, CK2a, CK2A1, CK2α, CKII, CSNK2A1

Observed MW

45 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

P68400

IMAGES