anti- CTNNA1 antibody

The anti-CTNNA1 antibody, available in a 100µg size, is a vital resource for researchers investigating cell adhesion and tissue integrity. CTNNA1, also known as alpha-catenin 1, is a key component of adherens junctions, playing a central role in cell-cell adhesion and tissue morphogenesis.

This polyclonal antibody is meticulously designed to target CTNNA1 with exceptional specificity and sensitivity, making it suitable for various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence.

Manufactured to the highest quality standards, our anti-CTNNA1 antibody is sourced from premium materials and undergoes rigorous validation to ensure reliability and reproducibility of results. Researchers can trust this antibody to deliver accurate data in their investigations.

The 100µg size provides researchers with an ample supply for multiple experiments and is compatible with a wide range of sample types, including cell lysates and tissue sections. Whether exploring the mechanics of adherens junctions or investigating developmental processes, this antibody is an indispensable tool for advancing your research.

Product Name

CTNNA1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

IMMUNOGEN INFORMATION

Immunogen

catenin(cadherin-associated protein), alpha 1, 102kDa

Synonyms

Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1

Observed MW

95-100 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:1000

UNIPROT INFORMATION

UniProt ID

P35221

IMAGES