anti- CUL2 antibody

The anti-CUL2 antibody, available in a 100µg size, is a crucial tool for researchers exploring the functions of Cullin-2 (CUL2) in various cellular processes, particularly its roles in protein ubiquitination and targeted protein degradation.

This polyclonal antibody is meticulously designed to target CUL2 with exceptional specificity and sensitivity, making it ideal for a wide range of applications, including Western blotting, immunohistochemistry, and co-immunoprecipitation assays.

Our anti-CUL2 antibody is sourced from high-quality materials and undergoes rigorous validation to ensure reliable and reproducible results. It is a trusted choice for researchers investigating the molecular mechanisms of protein turnover, cell cycle regulation, and ubiquitin ligase activity.

The 100µg size of this antibody provides researchers with an ample supply for multiple experiments, and it is compatible with various sample types, including cell lysates and tissue sections. Whether studying cell signaling, protein degradation pathways, or ubiquitin-dependent processes, this antibody is an invaluable resource for your research.

Product Name

CUL2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1(By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor(HIF).

IMMUNOGEN INFORMATION

Immunogen

cullin 2

Observed MW

87 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13617

IMAGES