anti- CXCL12 antibody

Our Anti-CXCL12 Antibody, available in a convenient 100µg size, is an indispensable tool for researchers investigating the complex roles of chemokines in immune responses, inflammation, and cancer biology.

CXCL12, also known as stromal cell-derived factor 1 (SDF-1), is a key chemokine involved in immune cell migration and tissue repair. With our Anti-CXCL12 Antibody, you can explore these intricate processes with confidence, knowing you have a reliable and highly specific tool for your research.

We have rigorously validated the specificity and sensitivity of this antibody to ensure consistent and accurate results in your experiments. Its compact size allows for versatile applications, whether you're conducting cell-based assays or in vivo studies. Trust in our Anti-CXCL12 Antibody to accelerate your scientific investigations and advance your understanding of these critical biological processes.

Product Name

CXCL12 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

IMMUNOGEN INFORMATION

Immunogen

chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)

Synonyms

SDF1, SDF1A, SDF1B

APPLICATION

Tested Application

ELISA, IHC

Recommended Dilution

IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P48061

IMAGES