anti- CXCR3B-specific antibody

Our Anti-CXCR3B-specific Antibody, available in a convenient 100µg size, is an invaluable tool for researchers focusing on the unique CXCR3B variant, a chemokine receptor with emerging significance in immune responses and inflammation.

CXCR3B is a distinct splice variant of the CXCR3 receptor and plays a pivotal role in modulating immune cell trafficking and inflammatory processes. Understanding its specific functions and interactions is essential for unraveling its contributions to immune responses. Our antibody has been meticulously developed to target CXCR3B with high specificity and sensitivity, ensuring reliable results in your experiments.

Its compact size allows for versatility in applications, whether you're conducting flow cytometry, immunohistochemistry, or in vivo studies. Trust in the quality of our Anti-CXCR3B-specific Antibody to advance your scientific investigations and contribute to a deeper understanding of chemokine receptor signaling.

Product Name

CXCR3B-specific antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CXCR3(C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells(PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury(PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4(PMID:12782716). This monoclonal antibody is specific to CXCR3B.

IMMUNOGEN INFORMATION

Immunogen

chemokine(C-X-C motif) receptor 3

Synonyms

CD183, CKR L2, CMKAR3, CXC R3, CXCR 3, CXCR3, CXCR3A, CXCR3B, G protein coupled receptor 9, GPR9, IP 10 receptor, IP10 R, Mig R, MigR

Observed MW

40 kDa +43 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:5000

UNIPROT INFORMATION

UniProt ID

P49682

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