anti- Cyclin D1 antibody

Our Anti-Cyclin D1 Monoclonal Antibody, available in a 100µg size, is a highly specific and reliable tool for researchers investigating cell cycle regulation and proliferation. Cyclin D1, a member of the Cyclin D family, plays a pivotal role in governing the progression of the cell cycle.

This monoclonal antibody offers exceptional specificity and sensitivity, enabling precise detection of Cyclin D1 in your experiments. Its compact size allows for versatility in applications, whether you're conducting Western blotting, immunohistochemistry, or cell cycle studies. With our Monoclonal Anti-Cyclin D1 Antibody, you can trust in the consistency and accuracy of your results, making it an essential resource for cell biology and cancer research.

Product Name

Cyclin D1 antibody

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

monoclonal

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

IMMUNOGEN INFORMATION

Immunogen

cyclin D1

Synonyms

B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31

Observed MW

36 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:2000-1:10000

UNIPROT INFORMATION

UniProt ID

P24385

IMAGES