anti- CYP1A1 antibody

Our Anti-CYP1A1 Antibody, available in a 100µg size, is an essential tool for researchers studying the cytochrome P450 enzyme CYP1A1, known for its role in the metabolism of polycyclic aromatic hydrocarbons (PAHs) and other environmental carcinogens.

Understanding the functions and genetic variations of CYP1A1 is essential for unraveling its contributions to detoxification processes, carcinogen metabolism, and its implications in cancer susceptibility and environmental exposures. Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring accurate and reproducible results in your experiments.

Its compact size allows for versatility in applications, whether you're conducting enzyme assays, studying PAH metabolism pathways, or assessing the impact of genetic polymorphisms. Trust in the quality of our Anti-CYP1A1 Antibody to accelerate your scientific investigations and contribute to advancements in pharmacology and environmental health research.

Product Name

CYP1A1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 1, subfamily A, polypeptide 1

Observed MW

63 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P04798

IMAGES