anti- CYP1B1 antibody

Our Anti-CYP1B1 Antibody, available in a 100µg size, is a crucial tool for researchers studying the cytochrome P450 enzyme CYP1B1, known for its role in the metabolism of various endogenous and exogenous compounds, including environmental toxins and estrogens.

Understanding the functions and genetic variations of CYP1B1 is essential for unraveling its contributions to hormone metabolism, detoxification processes, and its implications in hormone-related cancers and environmental exposures. Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring accurate and reproducible results in your experiments.

Its compact size allows for versatility in applications, whether you're conducting enzyme assays, investigating estrogen metabolism pathways, or assessing the impact of genetic polymorphisms. Trust in the quality of our Anti-CYP1B1 Antibody to accelerate your scientific investigations and contribute to advancements in pharmacology and cancer research.

Product Name

CYP1B1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 1, subfamily B, polypeptide 1

Observed MW

52 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q16678

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