anti- CYP26B1 antibody

Our Anti-CYP26B1 Antibody, available in a 100µg size, is a vital tool for researchers studying the cytochrome P450 enzyme CYP26B1, which plays a critical role in retinoic acid metabolism and signaling pathways.

CYP26B1 is involved in the breakdown of retinoic acid, a derivative of vitamin A that regulates various developmental processes, including embryogenesis, tissue regeneration, and cell differentiation. Understanding the functions and regulation of CYP26B1 is essential for unraveling its contributions to retinoid homeostasis and its implications in development and disease.

Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring accurate and reproducible results in your experiments. Its compact size allows for versatility in applications, whether you're conducting retinoic acid metabolism studies, investigating developmental pathways, or exploring potential therapeutic targets. Trust in the quality of our Anti-CYP26B1 Antibody to accelerate your scientific investigations and contribute to advancements in retinoid biology and developmental biology research.

Product Name

CYP26B1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Involved in the metabolism of retinoic acid(RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid(all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 26, subfamily B, polypeptide 1

Synonyms

CYP26A2, P450RAI2

Observed MW

58-60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NR63

IMAGES