anti- CYP3A4 antibody

Our Anti-CYP3A4 Antibody, available in a 100µg size, is a valuable tool for researchers studying the cytochrome P450 enzyme CYP3A4, one of the most abundant and versatile drug-metabolizing enzymes in the human liver and intestine.

CYP3A4 is responsible for the metabolism of a wide range of drugs and xenobiotics, making it a critical determinant of drug efficacy and safety. Understanding its functions, interactions, and genetic variations is essential for unraveling its contributions to drug metabolism and personalized medicine approaches.

Our antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in your experiments. Its compact size allows for versatility in applications, whether you're conducting drug metabolism studies, investigating drug-drug interactions, or assessing the impact of genetic polymorphisms. Trust in the quality of our Anti-CYP3A4 Antibody to accelerate your scientific investigations and contribute to advancements in pharmacology and personalized medicine research.

Product Name

CYP3A4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

IMMUNOGEN INFORMATION

Immunogen

cytochrome P450, family 3, subfamily A, polypeptide 4

Synonyms

CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1, cytochrome P450 3A4

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:20 - 1:200; IF: 1:20 - 1:200

UNIPROT INFORMATION

UniProt ID

P08684

IMAGES