anti- DACH1 antibody

Our Anti-DACH1 Antibody, available in a 100µg size, is a valuable tool for researchers investigating the role of DACH1 (Dachshund Homolog 1) in development and disease. DACH1 is a transcriptional cofactor involved in various signaling pathways and cellular processes, including tissue development and cancer progression.

Accurate detection of DACH1 is essential for understanding its functions and its potential implications in tissue development and tumorigenesis. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as immunohistochemistry, ChIP assays, and Western blotting.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DACH1 expression and function in different tissues and cell types. Trust in the quality of our Anti-DACH1 Antibody to advance your research and deepen your understanding of the intricate molecular processes governed by DACH1.

Product Name

DACH1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter(By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain(By similarity).

IMMUNOGEN INFORMATION

Immunogen

dachshund homolog 1(Drosophila)

Synonyms

DACH

Observed MW

97-100 kDa

APPLICATION

Tested Application

ELISA, IHC, IP, WB

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9UI36

IMAGES