anti- DACH2 antibody

Our Anti-DACH2 Antibody, available in a 100µg size, is a powerful tool for researchers studying the role of DACH2 (Dachshund Homolog 2) in development and disease. DACH2 is a transcriptional cofactor involved in various signaling pathways and cellular processes, including organogenesis and cancer progression.

Accurate detection of DACH2 is essential for understanding its functions and its potential implications in tissue development and tumorigenesis. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as immunohistochemistry, ChIP assays, and Western blotting.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DACH2 expression and function in different tissues and cell types. Trust in the quality of our Anti-DACH2 Antibody to advance your research and contribute to our understanding of DACH2's significance in development and disease.

Product Name

DACH2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression(By similarity). Probably binds to DNA via its DACHbox-N domain.

IMMUNOGEN INFORMATION

Immunogen

dachshund homolog 2(Drosophila)

Observed MW

65 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q96NX9

IMAGES