anti- DBI antibody

Our Anti-DBI (Diazepam Binding Inhibitor) Antibody, available in a 100µg size, is an essential tool for researchers studying DBI, a multifunctional protein involved in neurotransmission, steroidogenesis, and regulation of GABAergic signaling. DBI, also known as acyl-CoA-binding protein (ACBP), plays a pivotal role in diverse physiological processes.

Accurate detection of DBI is crucial for understanding its functions and its impact on brain function, stress responses, and metabolic regulation. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as immunohistochemistry and Western blotting.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DBI expression and function in different brain regions and under various physiological and pathological conditions. Trust in the quality of our Anti-DBI Antibody to advance your research and deepen your insights into the multifaceted roles played by DBI in neural and endocrine functions.

Product Name

DBI antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

IMMUNOGEN INFORMATION

Immunogen

diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)

Synonyms

DBI, ACBD1, ACBP, CCK-RP, EP, acyl-CoA-binding protein

Observed MW

12 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P07108

IMAGES