anti- DCLRE1B antibody

Our Anti-DCLRE1B (DNA Cross-Link Repair 1B) Antibody, available in a 100µg size, is a crucial tool for researchers investigating the role of DCLRE1B in DNA repair and genome stability maintenance. DCLRE1B is a key factor involved in homologous recombination and the resolution of DNA cross-links.

Accurate detection of DCLRE1B is essential for understanding its functions and its involvement in conditions such as cancer susceptibility and genomic instability. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as Western blotting and immunofluorescence.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DCLRE1B expression and function in different cell types and DNA repair pathways. Trust in the quality of our Anti-DCLRE1B Antibody to advance your research and deepen your insights into the intricate mechanisms governing DNA repair and genome integrity.

Product Name

DCLRE1B antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

IMMUNOGEN INFORMATION

Immunogen

DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)

Synonyms

SNM1B

Observed MW

60 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9H816

IMAGES