anti- DCUN1D1 antibody

Our Anti-DCUN1D1 (Defective in Cullin Neddylation 1 Domain-Containing 1) Antibody, available in a 100µg size, is an essential tool for researchers studying the role of DCUN1D1 in the regulation of cullin neddylation and its implications in protein degradation pathways.

Accurate detection of DCUN1D1 is crucial for understanding its functions and its impact on protein turnover and cellular responses. This antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as co-immunoprecipitation and Western blotting.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DCUN1D1 expression and interactions in different cellular contexts and under various proteostasis conditions. Trust in the quality of our Anti-DCUN1D1 Antibody to advance your research and deepen your insights into the intricate mechanisms governing protein quality control and cellular integrity.

Product Name

DCUN1D1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates(PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity).

IMMUNOGEN INFORMATION

Immunogen

DCN1, defective in cullin neddylation 1, domain containing 1

Synonyms

DCUN1L1, RP42, SCCRO

Observed MW

28 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q96GG9

IMAGES