anti- DDB1 antibody

Our Anti-DDB1 (DNA Damage-Binding Protein 1) Antibody, available in a 100µg size as a polyclonal antibody, is a versatile tool for researchers studying the role of DDB1 in DNA repair, cell cycle regulation, and protein degradation pathways. DDB1 is a scaffold protein that interacts with various partners and is involved in multiple cellular processes.

Accurate detection of DDB1 is crucial for understanding its functions and its impact on genome stability, cell division, and proteostasis. This polyclonal antibody has undergone rigorous validation for specificity and sensitivity, ensuring reliable results in applications such as Western blotting and immunoprecipitation.

With its 100µg size, this antibody provides ample material for multiple experiments, allowing you to explore DDB1 expression and interactions in different cellular contexts and under various experimental conditions. Trust in the quality of our Anti-DDB1 Antibody (Polyclonal) to advance your research and deepen your insights into the multifaceted roles played by DDB1 in cellular biology.

Product Name

DDB1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

IMMUNOGEN INFORMATION

Immunogen

damage-specific DNA binding protein 1, 127kDa

Synonyms

DDB p127 subunit, DDB1, DDBA, DNA damage binding protein 1, DNA damage binding protein a, HBV X associated protein 1, UV damaged DNA binding factor, UV DDB 1, UV

Observed MW

127 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

UNIPROT INFORMATION

UniProt ID

Q16531

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