anti- DIABLO antibody

The anti-DIABLO antibody, available in a 100µg size, is a valuable tool for researchers exploring DIABLO (Direct IAP-Binding Protein with Low pI), also known as Smac (Second Mitochondria-derived Activator of Caspases).

This antibody is meticulously designed to specifically target DIABLO with exceptional specificity and sensitivity, making it ideal for applications such as Western blotting, immunoprecipitation, and studies related to apoptosis, mitochondrial pathways, and cell death regulation.

Our anti-DIABLO antibody is sourced from high-quality materials and undergoes rigorous validation to ensure reliable and reproducible results. Researchers investigating the roles of DIABLO in the intrinsic apoptotic pathway, caspase activation, or its implications in cancer therapy will find this antibody indispensable for their work.

With a 100µg size, each vial provides ample supply for multiple experiments, allowing for flexibility in experimental design. Whether deciphering DIABLO's function in mitochondrial outer membrane permeabilization, chemotherapeutic resistance, or its involvement in disease progression, this antibody is an essential resource for your research.

Product Name

DIABLO antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.

IMMUNOGEN INFORMATION

Immunogen

diablo homolog(Drosophila)

Synonyms

DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3

Observed MW

20 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NR28

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