anti- DIO1 antibody

The anti-DIO1 antibody, available in a 100µg size, is a valuable tool for researchers investigating DIO1 (Deiodinase, Iodothyronine, Type I), an enzyme involved in thyroid hormone metabolism. This antibody offers high specificity and sensitivity, making it suitable for various applications, including Western blotting and immunohistochemistry.

DIO1 plays a critical role in the conversion of thyroxine (T4) to the biologically active triiodothyronine (T3), influencing thyroid hormone homeostasis. Researchers can use this antibody to explore the functions of DIO1 in thyroid hormone regulation and its potential implications in thyroid-related disorders.

The antibody undergoes stringent quality control measures to ensure consistent and reproducible results, providing researchers with the confidence to pursue their scientific inquiries effectively. With 100µg of product in each vial, researchers have an ample supply for multiple experiments, ensuring cost-effectiveness and experimental flexibility.

In summary, the anti-DIO1 antibody is a high-quality reagent that enables researchers to investigate the roles of DIO1 in thyroid hormone metabolism and its potential involvement in thyroid disorders. By studying DIO1, researchers can contribute to our understanding of thyroid hormone regulation and its impact on health and disease.

Product Name

DIO1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Responsible for the deiodination of T4(3,5,3',5'-tetraiodothyronine) into T3(3,5,3'-triiodothyronine) and of T3 into T2(3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

IMMUNOGEN INFORMATION

Immunogen

deiodinase, iodothyronine, type I

Synonyms

5DI, DIO1, DIOI, ITDI1, TXDI1, Type 1 DI, Type I 5 deiodinase

Observed MW

13 kDa, 29 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200

UNIPROT INFORMATION

UniProt ID

P49895

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