anti- DIS3 antibody

The anti-DIS3 antibody, available in a 100µg size, is a crucial reagent for researchers investigating DIS3 (DIS3 Exoribonuclease), an exoribonuclease involved in RNA processing and degradation pathways. This antibody offers high specificity and sensitivity, making it suitable for various applications, including Western blotting and immunohistochemistry.

DIS3 plays a central role in maintaining RNA homeostasis by degrading specific RNA substrates. Dysregulation of DIS3 has been implicated in various diseases, making it an important target for research. Researchers can use this antibody to explore the functions of DIS3 in RNA quality control, RNA degradation pathways, and its potential implications in disease pathogenesis.

The antibody undergoes stringent quality control measures to ensure consistent and reproducible results, providing researchers with the confidence to pursue their scientific inquiries effectively. With 100µg of product in each vial, researchers have an ample supply for multiple experiments, offering flexibility and cost-efficiency in their research designs.

In summary, the anti-DIS3 antibody is a high-quality reagent that empowers researchers to investigate the roles of DIS3 in RNA metabolism and its potential involvement in various diseases. By studying DIS3, researchers can uncover the molecular mechanisms underlying RNA quality control and its significance in cellular processes and disease development.

Product Name

DIS3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

IMMUNOGEN INFORMATION

Immunogen

DIS3 mitotic control homolog

Synonyms

KIAA1008, RRP44

Observed MW

110 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9Y2L1

IMAGES