anti- DIS3L2 antibody

The anti-DIS3L2 antibody, available in a 100µg size, is a valuable tool for researchers investigating the functions of the DIS3L2 (DIS3-like 3'-5' exoribonuclease 2) protein. DIS3L2 plays a crucial role in RNA metabolism and degradation, making it a key player in post-transcriptional regulation.

This antibody is designed to offer high specificity and sensitivity, making it suitable for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Researchers can confidently explore DIS3L2's functions in RNA decay pathways, RNA surveillance mechanisms, and its implications in diseases associated with RNA processing defects.

With 100µg of product per vial, researchers have an ample supply to perform multiple experiments, ensuring cost-effectiveness and flexibility in their research designs. The antibody undergoes stringent quality control measures to provide consistent and reproducible results, enabling scientists to advance their understanding of DIS3L2 biology.

Product Name

DIS3L2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem(ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

IMMUNOGEN INFORMATION

Immunogen

DIS3 mitotic control homolog-like 2

Synonyms

FAM6A

Observed MW

65 kDa/99 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q8IYB7

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