anti- DKK1 antibody

The anti-DKK1 antibody, available in a 100µg size, is a critical tool for researchers investigating DKK1 (Dickkopf-Related Protein 1), a secreted protein known for its pivotal roles in regulating Wnt signaling and its implications in skeletal development and diseases.

This antibody is meticulously designed for high specificity and sensitivity, making it ideal for applications such as Western blotting, immunohistochemistry, and studies exploring DKK1's functions in osteogenesis, tumor biology, and tissue homeostasis.

Our anti-DKK1 antibody is sourced from top-quality materials and subjected to stringent quality control to ensure reliable and reproducible results. Researchers investigating the impact of DKK1 in Wnt signaling pathways, bone metabolism, or its therapeutic potential will find this antibody to be an invaluable asset in their research.

With 100µg of product, each vial provides an ample supply for multiple experiments, allowing flexibility and cost-efficiency in research endeavors.

Product Name

DKK1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

IMMUNOGEN INFORMATION

Immunogen

dickkopf homolog 1

Synonyms

Dickkopf 1, Dickkopf related protein 1, DKK 1, DKK1, hDkk 1, SK

Observed MW

30-35 kDa

APPLICATION

Tested Application

ELISA, WB, IF, IHC

Recommended Dilution

WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

UNIPROT INFORMATION

UniProt ID

O94907

IMAGES