anti- DOCK7 antibody

Delve into the intricate world of Rho GTPase signaling and cellular dynamics with our meticulously crafted Anti-DOCK7 Antibody, now available in a 100µg size. Dedicator of Cytokinesis 7 (DOCK7) is a key guanine nucleotide exchange factor (GEF) that regulates Rho GTPases, contributing to processes like cell migration, cytoskeletal rearrangements, and neuronal development.

This antibody offers exceptional specificity and sensitivity, ensuring precise detection of DOCK7 in your research. Whether you're investigating neuronal migration, cell motility, or signaling pathways, this antibody is your key to unlocking the mysteries of these vital cellular processes.

Our high-quality Anti-DOCK7 Antibody undergoes rigorous quality control to guarantee consistent and reproducible results, enabling you to advance your research with confidence. Delve into the dynamic world of Rho GTPase signaling and the central role DOCK7 plays in these essential processes. Whether you're studying neurodevelopment, cancer metastasis, or tissue morphogenesis, this antibody is an indispensable tool for your research.

Product Name

DOCK7 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

IMMUNOGEN INFORMATION

Immunogen

dedicator of cytokinesis 7

Synonyms

dedicator of cytokinesis 7, DOCK7, KIAA1771, ZIR2

Observed MW

240 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:200-1:1000; IP: 1:500-1:1000

UNIPROT INFORMATION

UniProt ID

Q96N67

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