anti- Drosha antibody

Unlock the mysteries of RNA processing and gene regulation with our meticulously designed Anti-Drosha Antibody, now available in a 100µg size. Drosha, a ribonuclease III enzyme, is a central component of the microRNA biogenesis pathway and is of great interest to researchers investigating gene expression, RNA processing, and cancer biology.

This highly specific antibody empowers you to delve deep into the intricacies of Drosha and its roles with precision and confidence. It has undergone rigorous quality control to ensure accuracy and reproducibility in your experiments, making it the ideal choice for researchers exploring microRNA biology, gene regulation, and disease mechanisms.

Drosha plays a pivotal role in generating functional microRNAs and is implicated in various cellular processes and health conditions. Whether your research focuses on microRNA biogenesis, gene expression regulation, or cancer therapeutics, this antibody will be your invaluable research companion.

Product Name

Drosha antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Ribonuclease III double-stranded(ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA(miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts(pri-miRNAs) to release precursor miRNA(pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs(processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

IMMUNOGEN INFORMATION

Immunogen

ribonuclease type III, nuclear

Synonyms

RN3, RNASE3L, RNASEN

Observed MW

90 kDa, 151 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q9NRR4

IMAGES