anti- DTX3L antibody

Dive into the complexities of cellular signaling and signal transduction with our meticulously crafted Anti-DTX3L Antibody, now available in a 100µg size. Deltex E3 Ubiquitin Ligase 3-Like (DTX3L) is a central player in various cellular processes, making it an indispensable tool for researchers studying signal transduction, cell fate determination, and immune responses.

This highly specific antibody empowers you to investigate the intricacies of DTX3L and its functions with precision and confidence. It has undergone rigorous quality control to ensure accuracy and reproducibility in your experiments, making it an ideal choice for researchers studying Notch signaling pathways, cell differentiation, and disease mechanisms.

DTX3L is crucial for cellular responses and is often implicated in immune system function and disease-related pathways. Whether your research focuses on immune signaling cascades, developmental processes, or disease mechanisms, this antibody will be your invaluable research companion.

Product Name

DTX3L antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

IMMUNOGEN INFORMATION

Immunogen

deltex 3-like(Drosophila)

Synonyms

BBAP

Observed MW

84 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

Q8TDB6

IMAGES