anti- E2F1 antibody

Dive into the intricate world of cell cycle regulation and transcriptional control with our meticulously crafted Anti-E2F1 Antibody, available in a 100µg size. E2F1, a member of the E2F transcription factor family, is a central player in cell cycle progression, DNA replication, and gene expression.

This antibody is thoroughly validated for specificity, ensuring that your research on transcriptional regulation, cell cycle dynamics, and cancer biology is supported by a reliable tool.

E2F1's role in cell cycle control and its implications in cancer development have made it a subject of significant research interest. Whether your work is centered on cancer biology, gene regulation, or cell cycle dynamics, this antibody is an essential addition to your toolkit.

Product Name

E2F1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters(PubMed:20176812).

IMMUNOGEN INFORMATION

Immunogen

E2F transcription factor 1

Synonyms

RBBP3

Observed MW

55 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q01094

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