anti- E2F4 antibody

Immerse yourself in the world of transcriptional regulation with our high-quality Anti-E2F4 Antibody, now available in a 100µg size. E2F4, a member of the E2F transcription factor family, plays a crucial role in cell cycle progression, DNA replication, and gene expression.

This antibody is meticulously validated for specificity, ensuring that your research on transcriptional control, cell cycle dynamics, and cancer biology is supported by a reliable tool.

E2F4's role in cell cycle regulation and its implications in cancer development have made it a subject of significant research interest. Whether your work is centered on cancer therapeutics, gene regulation, or cell cycle dynamics, this antibody is an invaluable addition to your toolkit.

Product Name

E2F4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.

IMMUNOGEN INFORMATION

Immunogen

E2F transcription factor 4, p107/p130-binding

Observed MW

60-70 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q16254

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