anti- E2F8 antibody

Propel your studies in cell cycle regulation and transcriptional control with our meticulously crafted Anti-E2F8 Antibody, now available in a 100µg size. E2F8, a member of the E2F family of transcription factors, plays a crucial role in cell proliferation, DNA replication, and cell fate determination.

This antibody is rigorously tested for specificity, making it an invaluable tool for researchers delving into the intricacies of transcriptional regulation, cell cycle progression, and cancer biology.

E2F8's role in cell cycle control and its implications in cancer development have made it a subject of significant research interest. Whether your work is centered on cancer therapeutics, cell biology, or developmental processes, this antibody is your trusted companion.

Product Name

E2F8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

IMMUNOGEN INFORMATION

Immunogen

E2F transcription factor 8

Observed MW

82 kDa, 105 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

A0AVK6

IMAGES