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FNab02618

anti- E-cadherin antibody

anti- E-cadherin antibody

$290.00 USD
$290.00 USD
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Delve into the world of cell adhesion with our high-quality Anti-E-Cadherin Antibody, now available in a 100µg x2 size. E-Cadherin is a pivotal protein responsible for mediating calcium-dependent cell-cell adhesion, critical for maintaining tissue integrity and organ development.

Our antibody is rigorously tested for specificity, ensuring that your research on cell adhesion, epithelial-mesenchymal transition, and cancer metastasis is supported by a reliable tool.

E-Cadherin is a prominent marker of epithelial cells, and its role in cancer progression has garnered significant attention. Whether your research is focused on cancer biology, embryonic development, or tissue engineering, this antibody is an essential addition to your toolkit.

Product Name

E-cadherin antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

BACKGROUND

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

IMMUNOGEN INFORMATION

Immunogen

cadherin 1, type 1, E-cadherin (epithelial)

Synonyms

Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin

Observed MW

130 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500 - 1:1000; IHC: 1:50 - 1:200

UNIPROT INFORMATION

UniProt ID

P12830

IMAGES

 

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab02618( E-cadherin Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunofluorescent analysis of (10% Formaldehyde ) fixed A431 cells using FNab02618 (E-cadherin Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02618(E-cadherin antibody) at dilution of 1:1000

 

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