anti- EIF4EBP2 antibody

Explore the intricacies of translation initiation with our anti-EIF4EBP2 antibody. EIF4EBP2, also known as eukaryotic translation initiation factor 4E-binding protein 2, plays a central role in controlling protein synthesis. This 100µg antibody is your indispensable tool for in-depth investigation into EIF4EBP2.

EIF4EBP2 regulates translation by binding to eIF4E, thereby influencing the translation of specific mRNAs involved in cell growth and proliferation. Our antibody is meticulously designed to ensure precise results in a variety of research applications, including western blotting, immunoprecipitation, and immunofluorescence.

By using this antibody, you can gain valuable insights into the regulatory mechanisms that govern EIF4EBP2 and its impact on critical cellular processes. Whether you're conducting basic research, diagnostics, or drug development, this antibody offers reliable and reproducible results.

Product Name

EIF4EBP2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Repressor of translation initiation involved in synaptic plasticity, learning and memory formation(By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation(PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation(By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways(By similarity).

IMMUNOGEN INFORMATION

Immunogen

eukaryotic translation initiation factor 4E binding protein 2

Observed MW

~20 kDa

APPLICATION

Tested Application

ELISA, IHC, WB

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q13542

IMAGES