anti- EIF6 antibody

Uncover the role of EIF6 (Eukaryotic Translation Initiation Factor 6) with our Anti-EIF6 Antibody, available in a 100µg size. EIF6 is a critical factor involved in ribosome assembly, playing a pivotal role in protein synthesis and translational control.

This antibody is rigorously validated for specificity, ensuring its reliability for research on EIF6's function, its interactions with ribosomal subunits, and its implications in cellular processes. Whether your studies revolve around ribosome biogenesis, translation initiation, or gene regulation, this antibody is an indispensable addition to your scientific toolkit.

Enhance your understanding of EIF6 and its multifaceted functions by ordering your 100µg vial today. Dive into the world of ribosome assembly and protein synthesis with confidence.

Product Name

EIF6 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1(RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR(PubMed:26383020). Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species(ROS) synthesis(PubMed:26391622). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex(RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC(By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth(PubMed:21665150).

IMMUNOGEN INFORMATION

Immunogen

eukaryotic translation initiation factor 6

Synonyms

Itgb4bp

Observed MW

27-30 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

O55135

IMAGES