anti- ELL antibody

Uncover the intricacies of RNA polymerase II transcription with our anti-ELL antibody. ELL, or Elongation Factor for RNA Polymerase II, is an essential cofactor in the transcriptional elongation process. This 100µg antibody is your essential tool for exploring the functions and significance of ELL.

Investigate how ELL enhances the transcriptional activity of RNA polymerase II, facilitating the elongation of nascent transcripts. Our meticulously designed antibody ensures accurate and consistent results in a range of research applications, from chromatin immunoprecipitation to western blotting.

Explore the relevance of ELL in gene expression, its significance in disease mechanisms, and its potential as a therapeutic target. Whether you're conducting basic research, diagnostics, or drug development, this antibody empowers your scientific journey.

Product Name

ELL antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Elongation factor component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA(snRNA) gene transcription by RNA polymerase II and III(PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II-and III-dependent snRNA gene transcription(PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.

IMMUNOGEN INFORMATION

Immunogen

elongation factor RNA polymerase II

Synonyms

C19orf17

Observed MW

68-80 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P55199

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