anti- ELL2 antibody

Explore the world of RNA polymerase II transcriptional regulation with our anti-ELL2 antibody. ELL2, or Elongation Factor for RNA Polymerase II 2, is a critical component in facilitating transcriptional elongation. This 100µg antibody is your indispensable tool for investigating the functions and interactions of ELL2.

Investigate how ELL2 cooperates with the Super Elongation Complex (SEC) to promote the efficient elongation of RNA polymerase II-transcribed genes. Our meticulously designed antibody ensures accurate and reproducible results across research applications, providing you with the reliability you need for your experiments.

Delve into ELL2's role in gene regulation, its implications in disease mechanisms, and its potential as a therapeutic target. Whether you're engaged in basic research or translational studies, this antibody equips you with the tools to advance your scientific journey.

Product Name

ELL2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Elongation factor component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex(LEC), a complex required to regulate small nuclear RNA(snRNA) gene transcription by RNA polymerase II and III(PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain(IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.

IMMUNOGEN INFORMATION

Immunogen

elongation factor, RNA polymerase II, 2

Observed MW

72 kDa

APPLICATION

Tested Application

ELISA, WB, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

UNIPROT INFORMATION

UniProt ID

O00472

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