anti- EPHA8 antibody

Unlock the mysteries of cellular signaling with our Anti-EPHA8 Antibody, a crucial tool for studying EPHA8, a member of the Eph receptor family. With 100µg of high-quality antibody, you have the precision and reliability needed for your experiments.

EPHA8 is a key player in mediating cell adhesion, migration, and axon guidance, impacting various physiological processes, including neuronal development and tissue morphogenesis. Our antibody is meticulously tested for specificity and sensitivity, making it suitable for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence.

The Anti-EPHA8 Antibody is your essential tool for exploring EPHA8's functions with precision, contributing to a deeper understanding of cellular communication. Whether you're engaged in basic research or neuroscience studies, this antibody is a valuable asset, providing you with the confidence to advance your scientific inquiries and make significant strides in your work.

Product Name

EPHA8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).

IMMUNOGEN INFORMATION

Immunogen

EPH receptor A8

Synonyms

EEK, HEK3, KIAA1459

Observed MW

120 kDa

APPLICATION

Tested Application

ELISA, WB

Recommended Dilution

WB: 1:500-1:2000

UNIPROT INFORMATION

UniProt ID

P29322

IMAGES