anti- EPS8 antibody

Uncover the intricacies of cellular signaling with our Anti-EPS8 Antibody, a critical tool for studying EPS8 (Epidermal Growth Factor Receptor Substrate 8). With 100µg of high-quality antibody, you have the precision and reliability required for your experiments.

EPS8 is a key player in regulating cell morphology, cytoskeletal dynamics, and receptor-mediated signaling. Our antibody is rigorously tested for specificity and sensitivity, making it ideal for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence.

The Anti-EPS8 Antibody is your essential tool for exploring EPS8's functions with precision, contributing to a deeper understanding of cellular processes. Whether you're engaged in basic research or drug development, this antibody is a valuable asset, providing you with the confidence to advance your scientific inquiries and make significant strides in your work.

Product Name

EPS8 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor(GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.

IMMUNOGEN INFORMATION

Immunogen

epidermal growth factor receptor pathway substrate 8

Observed MW

97 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP, IF

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q12929

IMAGES