anti- ERCC2 antibody

Uncover the intricacies of DNA repair and genomic stability with our Anti-ERCC2 Antibody, a high-quality 100µg polyclonal antibody. ERCC2 is a pivotal component of the DNA repair machinery, playing a critical role in maintaining genomic integrity and preventing mutations.

This polyclonal antibody has been rigorously tested for specificity and sensitivity, making it suitable for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. Whether you're conducting basic research or investigating cancer therapies, this antibody offers the precision and reliability needed for successful experiments and meaningful discoveries.

The Anti-ERCC2 Polyclonal Antibody is your key to understanding the functions of ERCC2 and its contributions to DNA repair and genome stability.

Product Name

ERCC2 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

IMMUNOGEN INFORMATION

Immunogen

excision repair cross-complementing rodent repair deficiency, complementation group 2

Synonyms

XPD, XPDC

Observed MW

80 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

P18074

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