anti- ERI1 antibody

Uncover the mysteries of RNA metabolism and post-transcriptional regulation with our Anti-ERI1 Antibody, an indispensable tool for studying ERI1, a key enzyme involved in RNA degradation. With 100µg of high-quality antibody, you have the precision and reliability required for your experiments.

ERI1 is instrumental in shaping the cellular RNA landscape by participating in the decay of specific RNA species, impacting gene expression and RNA quality control. Our antibody is rigorously tested for specificity and sensitivity, making it ideal for techniques such as immunoblotting, immunoprecipitation, and immunofluorescence.

The Anti-ERI1 Antibody is your essential tool for exploring ERI1's functions with precision, contributing to a deeper understanding of RNA biology and the maintenance of cellular homeostasis. Whether you're engaged in basic research or RNA-based therapy development, this antibody is an invaluable asset, providing you with the confidence to advance your scientific inquiries and make significant strides in your work.

Product Name

ERI1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs(siRNAs) in vitro, suggesting a possible role as regulator of RNA interference(RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

IMMUNOGEN INFORMATION

Immunogen

exoribonuclease 1

Synonyms

3'EXO, THEX1

Observed MW

46kd

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q8IV48

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