anti- EXOSC1 antibody

Introducing our Anti-EXOSC1 Antibody, the indispensable tool for researchers delving into the complexities of RNA processing and degradation. EXOSC1, a vital component of the exosome complex, is at the heart of these processes and is a central focus for numerous scientific inquiries. This high-quality polyclonal antibody, available in a convenient 100µg size, empowers you to explore the multifaceted functions of EXOSC1 with accuracy and reliability.

Our Anti-EXOSC1 Antibody is the result of meticulous development and rigorous validation, ensuring exceptional specificity and sensitivity. Whether you're investigating EXOSC1's role in RNA quality control, mRNA degradation, or other cellular processes, this antibody delivers accurate and reproducible results, allowing you to focus on your research goals.

The 100µg size minimizes the need for frequent reordering, offering cost-efficiency and uninterrupted research. Whether you work with cell lines, tissue samples, or other experimental systems, this antibody seamlessly adapts to a wide range of research applications.

Product Name

EXOSC1 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

IMMUNOGEN INFORMATION

Immunogen

exosome component 1

Synonyms

CSL4

Observed MW

21 kDa

APPLICATION

Tested Application

ELISA, WB, IHC

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9Y3B2

IMAGES