anti- EXOSC3 antibody

Unleash the potential of your molecular biology research with our Anti-EXOSC3 Antibody. As a key component of the exosome complex, EXOSC3 is at the heart of RNA processing and degradation, making it a critical target for numerous scientific inquiries. Our high-quality polyclonal antibody, conveniently available in a 100µg size, is your gateway to exploring the intricacies of RNA biology.

This meticulously developed and rigorously validated Anti-EXOSC3 Antibody offers exceptional specificity and sensitivity, ensuring that your research produces reliable and accurate results. Whether you're delving into RNA quality control, gene regulation, or other aspects of RNA biology, this antibody provides the confidence you need to advance your investigations.

The 100µg size is designed to minimize the need for frequent reordering, allowing you to focus on your research without interruption. Whether you're working with cell lines, tissue samples, or other experimental systems, this antibody seamlessly adapts to a wide range of research applications.

Product Name

EXOSC3 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.

IMMUNOGEN INFORMATION

Immunogen

exosome component 3

Synonyms

RRP40

Observed MW

31 kDa

APPLICATION

Tested Application

ELISA, WB, IHC, IP

Recommended Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NQT5

IMAGES