anti- EXOSC4 antibody

Welcome to the forefront of molecular biology research with our Anti-EXOSC4 Antibody, a powerful tool designed to enhance your experimental capabilities. EXOSC4, a vital component of the exosome complex, plays a pivotal role in RNA processing and degradation, making it a focal point for a wide array of investigations. This high-quality polyclonal antibody, available in a convenient 100µg size, is your trusted partner for unraveling the secrets of RNA biology.

Our Anti-EXOSC4 Antibody has been meticulously developed and rigorously validated to deliver exceptional specificity and sensitivity. It empowers you to explore the multifaceted functions of EXOSC4, including its involvement in RNA quality control, RNA degradation, and more. This antibody ensures reliable and accurate results for your research needs.

With 100µg at your disposal, this antibody minimizes the need for frequent reordering, maximizing cost-efficiency. Whether your research spans cell culture, tissue samples, or other experimental systems, this antibody seamlessly adapts to diverse research applications.

Product Name

EXOSC4 antibody

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

polyclonal

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.

IMMUNOGEN INFORMATION

Immunogen

exosome component 4

Synonyms

RRP41, SKI6

Observed MW

27kd

APPLICATION

Tested Application

ELISA, WB, IHC, IF

Recommended Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

UNIPROT INFORMATION

UniProt ID

Q9NPD3

IMAGES